Milton Packer Selected Research

flosequinan

1/2017	Long-Term Effects of Flosequinan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the PROFILE Trial After 24 Years.
1/2005	Cardiac troponin I, a possible predictor of survival in patients with stable congestive heart failure.
11/2002	Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan.

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Milton Packer Research Topics

Disease

235	Heart Failure 10/2022 - 06/2002
22	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2017
18	Atrial Fibrillation 01/2022 - 05/2007
16	Cardiomyopathies (Cardiomyopathy) 01/2022 - 08/2013
16	Inflammation (Inflammations) 01/2021 - 01/2018
16	Fibrosis (Cirrhosis) 01/2021 - 01/2017
14	Disease Progression 01/2021 - 08/2013
12	Hypotension (Low Blood Pressure) 01/2022 - 04/2013
10	Left Ventricular Dysfunction 01/2020 - 08/2002
10	Obesity 01/2020 - 01/2018
9	Sudden Death 01/2022 - 07/2002
8	Myocardial Infarction 01/2022 - 12/2003
8	Diabetes Mellitus 01/2021 - 11/2014
6	Chronic Renal Insufficiency 01/2021 - 12/2004
6	Polycythemia (Erythrocytosis) 01/2021 - 12/2016
6	Hypoxia (Hypoxemia) 01/2021 - 01/2020
6	Stroke (Strokes) 01/2020 - 01/2017
5	Hyperkalemia 01/2022 - 09/2014
5	Heart Diseases (Heart Disease) 01/2022 - 01/2017
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 04/2015
4	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 01/2020
4	Cardiotoxicity 12/2019 - 12/2016
4	Edema (Dropsy) 10/2019 - 08/2013
3	Chronic Obstructive Pulmonary Disease (COPD) 10/2022 - 01/2021
3	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 01/2018
3	Body Weight (Weight, Body) 01/2021 - 01/2017
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 10/2020 - 08/2015
3	Weight Loss (Weight Reduction) 01/2020 - 12/2016
3	Muscular Diseases (Myopathy) 01/2020 - 12/2019
3	Angioedema 10/2019 - 02/2004
3	Confusion (Bewilderment) 01/2019 - 09/2016
2	Prediabetic State (Prediabetes) 08/2022 - 01/2021

Drug/Important Bio-Agent (IBA)

66	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 10/2012
51	Neprilysin (Neutral Endopeptidase)IBA 01/2022 - 08/2002
36	empagliflozinIBA 10/2022 - 01/2017
34	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2021 - 10/2012
32	Enalapril FDA LinkGeneric 01/2022 - 08/2002
32	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021 - 08/2002
27	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2022 - 12/2003
27	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 01/2017
27	SodiumIBA 01/2022 - 01/2017
24	Pharmaceutical PreparationsIBA 10/2021 - 02/2005
23	Sodium-Glucose Transport ProteinsIBA 02/2022 - 01/2017
23	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2012
21	pro-brain natriuretic peptide (1-76)IBA 10/2022 - 03/2004
17	Natriuretic PeptidesIBA 01/2022 - 07/2014
16	paragonIBA 01/2022 - 01/2017
13	Valsartan (Vals)FDA Link 01/2022 - 10/2012
12	Biomarkers (Surrogate Marker)IBA 10/2022 - 10/2018
12	DiureticsIBA 01/2022 - 07/2002
10	Sirtuin 1IBA 01/2021 - 01/2020
10	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 10/2017
10	Carvedilol (Coreg)FDA LinkGeneric 08/2017 - 10/2002
9	Insulin (Novolin)FDA Link 10/2022 - 10/2017
9	AngiotensinsIBA 01/2022 - 09/2014
9	Mineralocorticoid Receptor AntagonistsIBA 01/2022 - 01/2006
9	AdipokinesIBA 01/2021 - 10/2017
9	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 11/2020 - 08/2002
8	Troponin T (Troponin T1)IBA 10/2022 - 11/2014
8	Angiotensin Receptor AntagonistsIBA 01/2021 - 06/2014
7	Digoxin (Digitek)FDA LinkGeneric 01/2022 - 05/2004
7	SymportersIBA 12/2021 - 01/2018
7	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 02/2018
5	PotassiumIBA 01/2022 - 01/2017
5	AldosteroneIBA 10/2018 - 10/2017
4	Uric Acid (Urate)IBA 01/2022 - 01/2018
4	LeptinIBA 01/2021 - 01/2018
4	LipidsIBA 01/2021 - 01/2020
4	Oxygen (Dioxygen)IBA 01/2021 - 01/2020
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 01/2018
4	Sodium-Hydrogen ExchangersIBA 01/2021 - 01/2017
4	Trinitrotoluene (TNT)IBA 01/2021 - 11/2014
4	EnzymesIBA 11/2020 - 12/2016
4	aliskiren FDA Link 01/2020 - 10/2017
4	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2020 - 01/2018
4	ThiazolidinedionesIBA 01/2020 - 01/2018
4	Peptides (Polypeptides)IBA 01/2020 - 01/2017
4	Spironolactone (Aldactone)FDA LinkGeneric 01/2018 - 01/2006
4	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2018 - 01/2018
4	Vasodilator Agents (Vasodilators)IBA 01/2017 - 11/2002
3	Erythropoietin FDA Link 01/2021 - 01/2020
3	Hemoglobins (Hemoglobin)IBA 01/2021 - 01/2016
3	TroponinIBA 01/2021 - 11/2014
3	Protein Isoforms (Isoforms)IBA 09/2020 - 11/2002
3	dapagliflozinIBA 01/2020 - 10/2019
3	AMP-Activated Protein KinasesIBA 01/2020 - 01/2020
3	Adenosine Monophosphate (AMP)IBA 01/2020 - 01/2018
3	Biological ProductsIBA 10/2019 - 01/2018
3	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2018 - 01/2018
3	flosequinanIBA 01/2017 - 11/2002
3	Bosentan (Tracleer)FDA Link 01/2017 - 02/2005
3	omapatrilatIBA 08/2005 - 08/2002
2	AlbuminsIBA 10/2022 - 01/2021

Therapy/Procedure

61	Therapeutics 08/2022 - 06/2002
9	Catheter Ablation 01/2021 - 01/2018
5	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2022 - 01/2019
4	Cardiac Resynchronization Therapy 01/2022 - 06/2002
3	Critical Care (Surgical Intensive Care) 10/2021 - 01/2015
3	Patient Readmission 01/2020 - 01/2016
2	Defibrillators (Defibrillator) 01/2022 - 02/2016